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BRANCHED-CHAIN AMINO ACIDS OVERVIEW INFORMATION

Branched-chain amino acids are essential nutrients that the body obtains from proteins found in food, especially meat, dairy products, and legumes. They include leucine, isoleucine, and valine. “Branched-chain” refers to the chemical structure of these amino acids. People use branched-chain amino acids for medicine.

Branched-chain amino acids are used to treat amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), brain conditions due to liver disease (chronic hepatic encephalopathy, latent hepatic encephalopathy), a movement disorder called tardive dyskinesia, a genetic disease called McArdle's disease, a disease called spinocerebellar degeneration, and poor appetite in elderly kidney failure patients and cancer patients. Branched-chain amino acids are also used to help slow muscle wasting in people who are confined to bed.

Some people use branched-chain amino acids to prevent fatigue and improve concentration.

Athletes use branched-chain amino acids to improve exercise performance and reduce protein and muscle breakdown during intense exercise.

Healthcare providers give branched-chain amino acids intravenously (by IV) for sudden brain swelling due to liver disease (acute hepatic encephalopathy) and also when the body has been under extreme stress, for example after serious injury or widespread infection.

How does it work?
Branched-chain amino acids stimulate the building of protein in muscle and possibly reduce muscle breakdown. Branched-chain amino acids seem to prevent faulty message transmission in the brain cells of people with advanced liver disease, mania, tardive dyskinesia, and anorexia.

Branched-chain amino acid (BCAA)

Other Names: Acide Isovalérique de Leucine, Acides Aminés à Chaîne Ramifiée, Acides Aminés Ramifiés, Aminoacidos Con Cadenas Laterales Ramificadas, BCAA, BCAAs, Branched Chain Amino Acid Therapy, Branched Chain Amino Acids, Isoleucine, Isoleucine Ethyl Ester HCl, Leucine, Leucine Ethyl Ester HCl, Leucine Isovaleric Acid, Leucine Methyl Ester HCl, L-Isoleucine, L-Leucine, L-Leucine Pyroglutamate, L-Valine, N-Acetyl Leucine, N-Acétyl Leucine, Valine, 2-amino-3-methylvaleric acid, 2-amino-4-methylvaleric acid, 2-amino-3-methylbutanoic acid.

A branched-chain amino acid (BCAA) is an amino acid having aliphatic side-chains with a branch (a carbon atom bound to more than two other carbon atoms). Among the proteinogenic amino acids, there are three BCAAs: leucine, isoleucine and valine. The BCAAs are among the nine essential amino acids for humans, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. BCAAs have been used clinically to aid in the recovery of burn victims. They are also used in the treatment in some cases of hepatic encephalopathy.

A recent study suggested that the reduction in blood BCAAs may be associated with improvement in blood sugar regulation. The mechanism remains unknown.

Another recent study suggests genetic mutations in some autism models lead to altered branched chain amino acid pathways that might be normalized with dietary supplementation.

Cota et al (1) demonstrated in 2006 that BCAAs, particularly leucine, also affect the mTOR pathway, signaling two regions of the brain. These signals decrease food intake and increase basic metabolic rate. These results led to a clinical trial by Ordman (3) to develop a nutraceutical method for controlling weight gain in humans. The potential of nutrients to signal changes in metabolism is exemplified by how BCAAs may increase muscle repair, but it is important to be aware how it may also decrease appetite.




Description/ Specification of Branched Chain Amino Acids

The three essential amino acids, Isoluucine, Leucine and Valine are collectively known as Branched Chain Amino Acids BCAA’s are used by muscle fibers during exercise and promote anabolic and anti – catabolic effects.The body prefers to use BCAAs during periods of exercise as a source of energy.

Effective for:
- Improving muscle control and mental function in people with advanced liver disease (latent hepatic encephalopathy).
- Reducing muscle breakdown during exercise.
- Decreasing symptoms associated with mania.
- Reducing movements associated with tardive dyskinesia, a disorder associated with the - use of antipsychotic medications.
- Reducing loss of appetite and improving nutrition in elderly patients on hemodialysis.
 
BRANCHED-CHAIN AMINO ACIDS DOSING

The following doses have been studied in scientific research:

BY MOUTH:
For a brain condition due to liver disease (hepatic encephalopathy): 240 mg/kg/day up to 25 grams of branched-chain amino acids.
For mania: a 60 gram branched-chain amino acid drink containing valine, isoleucine, and leucine in a ratio of 3:3:4 every morning for 7 days.
For tardive dyskinesia: a branched-chain amino acid drink containing valine, isoleucine, and leucine at a dose of 222 mg/kg taken three times daily for 3 weeks.
For anorexia and improving overall nutrition in elderly malnourished hemodialysis patients: granules of branched-chain amino acids consisting of valine, leucine, and isoleucine at a dose of 4 grams taken three times daily.
The estimated average requirement (EAR) of branched-chain amino acids is 68 mg/kg/day (leucine 34 mg, isoleucine 15 mg, valine 19 mg) for adults. However, some researchers think earlier testing methods may have underestimated this requirement and that the requirement is really about 144 mg/kg/day. Other researchers think the EARs for children are also low. EARs for branched-chain amino acids for children are: ages 7-12 months, 134 mg/kg/day; 1-3 years, 98 mg/kg/day; 4-8 years, 81 mg/kg/day; boys 9-13 years, 81 mg/kg/day; girls 9-13 years, 77 mg/kg/day; boys 14-18 years, 77 mg/kg/day; girls 14-18 years, 71 mg/kg/day.

INTRAVENOUS (IV):
Healthcare providers give branched-chain amino acids intravenously (by IV) for brain enlargement due to liver disease (hepatic encephalopathy).

Branched-chain amino acid (BCAA) Packing

 Packaging:  1 kg, 5 kg, 10 kg, 20 kg bags

   

Note :- Rate of the products Mention in the Website will be verified by day to day fluctuation in the Indian Agro Market  Actual Rate of the Products will be provide at the time of final Confirmation of Order
 

PDF of COA (Certificate Of Analysis)