Chlorophacinone is a
chlorinated, diphenyl
indane derivative;
an anti-coagulant and
metabolic inhibitor
which is highly toxic to
rodents but of only
slight toxicity to
humans and other
non-target
organisms. It is
compatible with a wide
spectrum of bait
carriers
and has no repellent
action.
1.3 SELECTED PROPERTIES
1.3.1 Physical
characteristics
Chlorophacinone is a
white crystalline solid.
It has a melting
point of 140°C, it is
non-corrosive.
1.3.2 Solubility
Chlorophacinone is
sparingly soluble in
water, but soluble in
organic solvents.
1.3.3 Stability
Chlorophacinone is
described as stable and
resistant to
weathering effects.
1.3.4 Vapour pressure
Negligible at 20°C.
1.4 AGRICULTURE,
HORTICULTURE AND
FORESTRY
1.4.1 Common
formulations
Chlorophacinone is
available as a bait,
50-250 mg a.i./kg and
in oil solution, 2.5 g
a.i./L.
1.4.2 Pests controlled
Presently used against
mice, moles, muskrats,
rats, vampire
bats, and voles - in
controlled access areas
and under field
conditions.
1.4.3 Use pattern
Chlorophacinone is
applied wherever the
rodents have access to
the bait. It may be
replenished as it is
consumed. A tracking
powder
is recommended in areas
where rodents travel. It
does not usually
require more than one
feeding for a kill. The
oil solution may be
used to impregnate or
coat any desirable bait.
Prevent food
contamination.
1.4.4 Unintended effects
Chlorophacinone could be
hazardous to other small
mammals and
birds if used
indiscriminately.
Persons with bleeding
problems and
children should not come
in contact.
1.5 PUBLIC HEALTH USE
As in 1.4, for control
of nuisance and disease
vector rodent
pests.
1.6 HOUSEHOLD USE
As in 1.4, for control
of nuisance and disease
vector rodent
pests.
2. TOXICOLOGY AND RISKS
2.1 TOXICOLOGY - MAMMALS
2.1.1 Absorption route
Chlorophacinone is
primarily absorbed from
the gastrointestinal
tract; dermal absorption
may also occur.
2.1.2 Mode of action
Chlorophacinone is an
anticoagulant agent; it
uncouples
oxidative
phosphorylation
depressing hepatic
synthesis of
prothrombin and clotting
factors VII, IX and X
and, it causes direct
damage to capillary
permeability. The
ultimate effect is
widespread
internal haemorrhage. In
rodents, indandlones
also cause neurologic
and cardiopulmonary
injuries which often
lead to death before
haemorrhage occurs.
2.1.3 Excretion products
No published information
available.
2.1.4 Toxicity, single
dose
A single dose of a 50
mg/kg bait kills Rattus
norvegicus from
the fifth day.
Oral LD50:
Rat 20.5 mg/kg bw;
technical material
Rabbit 50.0 mg/kg bw;
technical material
Dermal LD50:
Rabbit 200.0 mg/kg bw;
technical material
A solution of 5 mg in 2
ml of liquid paraffin
applied to 100
cm2 of shaved skin on
rabbits caused only a
slight reduction of
prothrombin rating.
2.1.5 Toxicity, repeated
doses
Chlorophacinone is of
low toxicity to birds.
Administration of
15 daily doses of 2.25
mg to grey partridges
produced no ill-
effects.
Oral LD50:
Wild Birds 430 mg/kg bw;
technical material
Ducks 100 mg/kg bw;
technical material
3. FOR REGULATORY
AUTHORITIES -
RECOMMENDATION ON
REGULATION OF
COMPOUND
3.1 RECOMMENDED
RESTRICTIONS ON
AVAILABILITY
Product
Name:
CHLOROPHACINONE
Common Name:
CHLOROPHACINONE
Molecular formula:
C23H15ClO3
Molecular weight: 374.8
CAS Number: [3691-35-8]
Specification: 98%TECH
Packing:1kg/aluminum
bag
Certification ISO9001,
FAO standard
Place of Origin: India
Payment:
Delivery time: 15 days
Trademark:
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